Glycolic Acid → (5-ethoxy-3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol
Reaktionsgleichung
[NH2:1][C:2]1[C:3]([NH:11][CH3:12])=[N:4][C:5]([O:8][CH2:9][CH3:10])=[CH:6][CH:7]=1.[C:13]([OH:17])(=O)[CH2:14]O>>[CH2:9]([O:8][C:5]1[N:4]=[C:3]2[N:11]([CH3:12])[C:14]([CH2:13][OH:17])=[N:1][C:2]2=[CH:7][CH:6]=1)[CH3:10]Komponenten
3
Versuchsvorschrift
A procedure similar to that described in Preparation 43 was repeated, except that 4.15 g 3-amino-6-ethoxy-2-methylaminopyridine (prepared as described in Preparation 97), and 5.66 g of glycolic acid were used, and that the product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 3.20 g of the title compound, melting at 161° C.
Aufarbeitung
- customA procedure similar to that described in Preparation 43
- customthat the product was purified by column chromatography through silica gel
- additionby volume mixture of ethyl acetate and methanol as the eluent
Quellen und Nachweise
- ORD-Eintrag
- ord-196fb2361a484945a5d4403c023da216
- Quelldatensatz
- uspto-grants-2000_09
- Patentnummer
- US06117893
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