Potassium Carbonate → 2-Cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

HRID 1953841Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1953841
[CH:1]1([C:4]2C(OC3C=CC(C4C=CC=CC=4C4N=NN(C(OC(=O)C(C)(C)C)C(C)C)N=4)=CC=3)=C(C(O)=O)C3C(=CC=CC=3)N=2)[CH2:3][CH2:2]1.[CH:46]1([C:49]2[C:58]([O:59][C:60]3[CH:65]=[CH:64][C:63]([C:66]4[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=4[C:72]4[N:73]=[N:74][N:75]([C:77]([C:90]5[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=5)([C:84]5[CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=5)[C:78]5[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=5)[N:76]=4)=[CH:62][CH:61]=3)=[C:57]([C:96]([OH:98])=[O:97])[C:56]3[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=3)[N:50]=2)[CH2:48][CH2:47]1.[C:99](=[O:102])([O-:101])[O-:100].[K+].[K+]>CN(C)C=O.C(OCC)(=O)C>[CH:46]1([C:49]2[C:58]([O:59][C:60]3[CH:61]=[CH:62][C:63]([C:66]4[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=4[C:72]4[N:73]=[N:74][N:75]([C:77]([C:90]5[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=5)([C:78]5[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=5)[C:84]5[CH:85]=[CH:86][CH:87]=[CH:88][CH:89]=5)[N:76]=4)=[CH:64][CH:65]=3)=[C:57]([C:96]([O:98][CH2:4][C:1]3[O:102][C:99](=[O:101])[O:100][C:2]=3[CH3:3])=[O:97])[C:56]3[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=3)[N:50]=2)[CH2:47][CH2:48]1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 100774042-Cyclopropyl-3-[[2'-[2-[1-(2,2-dimethyl-1-oxopropoxy)-2-methylpropyl]-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acidHCID 23298234HCID 23298234, Verbindung

Produkt 1

HCID 571027302-Cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To the title A compound of Example 17, 2-cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid (1.32 g, 1.91 mmol, 1 eq.), and the title B compound (1.84 g, 9.54 mmol, 5 eq.) in dimethylformamide (3.8 mL, 0.5M), potassium carbonate (0.66 g, 4.77 mmol, 2.5 eq.) was added. The mixture was stirred at room temperature for 21 hours, diluted with ethyl acetate and filtered. The filtrate was washed with ammonium chloride/water and saturated sodium chloride, dried (magnesium sulfate), filtered and concentrated to afford the title compound.

Aufarbeitung

  1. filtrationfiltered
  2. washThe filtrate was washed with ammonium chloride/water and saturated sodium chloride
  3. dry with materialdried (magnesium sulfate)
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-8425e42db29e42a490c7e9a96d46d5bc
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06117885

Notizen zur Reaktion

Wird geladen…