Pentadecanoic Acid → Pentadecanoyl chloride

HRID 1953925

Reaktionsgleichung

Reaktionsgleichung von HRID 1953925
S(Cl)([Cl:3])=O.[C:5]([OH:21])(=O)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>C1(C)C=CC=CC=1>[C:5]([Cl:3])(=[O:21])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

Komponenten

4

Edukt 2

HCID 13849Pentadecanoic AcidHCID 24386Thionyl Chloride

Produkt 1

HCID 263097Pentadecanoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

C 18 resin: Pentadecanoyl chloride was synthesized by reacting 10 ml of 2 M thionyl chloride in 10 ml of toluene with 1.5 gm pentadecanoic acid. After 40 minutes of refluxing, the remaining thionyl chloride and toluene were removed by distillation. 4 gm of the 3-amino-propyl resin was then incubated overnight with the freshly prepared pentadecanoyl chloride in pyridine. The next day, the resin was twice washed with methylene chloride and then three times more with methanol and dried.

Aufarbeitung

  1. temperatureAfter 40 minutes of refluxing
  2. customthe remaining thionyl chloride and toluene were removed by distillation
  3. washThe next day, the resin was twice washed with methylene chloride
  4. dry with materialthree times more with methanol and dried

Quellen und Nachweise

ORD-Eintrag
ord-d0cfdd032eed4c3b97c2047641393aec
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06119699

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