Ethanol → 1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

HRID 19548

Reaktionsgleichung

Reaktionsgleichung von HRID 19548
[CH2:1]([O:3][C:4]([C:6]1[CH:7](Br)[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2].[CH2:24]([OH:26])[CH3:25]>[N+]([O-])([O-])=O.[Ag+]>[CH2:1]([O:3][C:4]([C:6]1[CH:7]([O:26][CH2:24][CH3:25])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 686984701-bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

Produkt 1

HCID 116601011-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl esterAusbeute 52 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24470Silver NitrateKatalysator

Versuchsvorschrift

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

Aufarbeitung

  1. filtrationfiltered
  2. customThe organic layer was separated
  3. concentrationconcentrated under a reduced pressure
  4. customThe resulting residue was purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-87633b90324c42a59e3bb02d07e2d09b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745439B2

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