Ethyl 3-(2-fluorophenyl)prop-2-enoate → Ethyl 3-(2-fluorophenyl)propanoate

HRID 1954873Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1954873
[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H]>C(O)C.O.[Pt]=O>[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

Komponenten

5

Edukt 2

HCID 590919Ethyl 3-(2-fluorophenyl)prop-2-enoateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 14879014Ethyl 3-(2-fluorophenyl)propanoateAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 86587499Platinum oxide monohydrateKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 2-fluorocinnamate (29.25 g, 0.176 mol) and platinum oxide hydrate (0.25, EM Scientific) in 95% ethanol (150 mL) was placed on a Parr hydrogenation apparatus and shaken under 2-4 atm at hydrogen pressure. After the appropriate amount of hydrogen was consumed, the catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give 29.39 g (99%) of crude ethyl 3-(2-fluorophenyl)propionate. This material was used without further purification.

Aufarbeitung

  1. customAfter the appropriate amount of hydrogen was consumed
  2. customthe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3f6994e5961c472785da87f605f3ac44
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06124284

Notizen zur Reaktion

Wird geladen…