Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide → HCID 18183096, Verbindung

HRID 1955480Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1955480
[OH:1][CH2:2][C:3]1[N:4]=[C:5]2[N:9]([CH:10]=1)[CH2:8][CH2:7][S:6]2(=[O:12])=[O:11]>C(#N)C.[O-2].[O-2].[Mn+4]>[S:6]1(=[O:12])(=[O:11])[CH2:7][CH2:8][N:9]2[CH:10]=[C:3]([CH:2]=[O:1])[N:4]=[C:5]12

Komponenten

4

Edukt 1

HCID 18183097Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide

Produkt 1

HCID 18183096HCID 18183096, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysator2×HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2,3-Dihydro-6-hydroxymethylimidazo[2,1-b]thiazole-1,1-dioxide (207 mg, 1.1 mmol) was dissolved in acetonitrile (minimum volume) and treated with manganese dioxide (621 mg, 3 wt. equivalents) and the mixture stirred vigorously at ambient temperature. After 1 h, more manganese dioxide (621 mg) was added and the mixture sitrred for a further 18 h. The mixture was filtered through Celite, the filter bed washed with acetonitrile, the filtrate and washings combined and evaporated to dryness under reduced pressure. The residue was triturated under dichloromethane and the resulting solid collected by filtration, washed with dichloromethane and dried in air (108 mg, 53%) (Found: M+ 186.0103. C6H6 N2O3S requires M 186.0099); nmax (Nujol) 1691, 1320 and 1132 cm-1 ; dH [250MHz; (CD3)2SO] 4.25 (2H, t, J 7Hz), 4.68 (2H, t, J 7Hz), 8.32 (1H, s), 9.81 (1H, s).

Aufarbeitung

  1. waitthe mixture sitrred for a further 18 h
  2. filtrationThe mixture was filtered through Celite
  3. washthe filter bed washed with acetonitrile
  4. customevaporated to dryness under reduced pressure
  5. customThe residue was triturated under dichloromethane
  6. filtrationthe resulting solid collected by filtration
  7. washwashed with dichloromethane
  8. customdried in air (108 mg, 53%) (Found: M+ 186.0103. C6H6 N2O3S requires M 186.0099)

Quellen und Nachweise

ORD-Eintrag
ord-7a9c097a7691410cab229dc5f030de04
Quelldatensatz
uspto-grants-1998_07
Patentnummer
US05776455

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