Hydrochloric Acid → 3-Methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

Beteiligte Stoffe

Reaktionsschritte

A mixture of iN sodium methylate (162 ml), o-phenylenediamine (17.5 g, 162 mmol) and diethyl 2-(methoxyimino)malonate (32.91 g, 162 mmol) is heated to reflux for 5 hr. After cooling, the mixture is acidified with 2N HCl (162 ml) and pale yellowish crystals (14.3 g, 41%) are filtered off.

Herkunft & Nachweise