6-Ethoxy-2-pyridinamine → Ethyl 6-ethoxy-4-(6-ethoxy-2-pyridylamino)-7-methyl-1,8-naphthyridine-3-carboxylate sesquihydrochloride hydrate
Reaktionsgleichung
[Cl:1][C:2]1[C:11]2[C:6](=[N:7][C:8]([CH3:15])=[C:9]([O:12][CH2:13][CH3:14])[CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([O:18][CH2:19][CH3:20])=[O:17].[NH2:21][C:22]1[N:27]=[C:26]([O:28][CH2:29][CH3:30])[CH:25]=[CH:24][CH:23]=1>Cl>[OH2:12].[ClH:1].[CH2:13]([O:12][C:9]1[CH:10]=[C:11]2[C:6](=[N:7][C:8]=1[CH3:15])[N:5]=[CH:4][C:3]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:2]2[NH:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([O:28][CH2:29][CH3:30])[N:27]=1)[CH3:14].[ClH:1].[ClH:1].[CH2:19]([O:18][C:16]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[NH:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]([O:28][CH2:29][CH3:30])[N:27]=1)=[CH:10][C:9]([O:12][CH2:13][CH3:14])=[C:8]([CH3:15])[N:7]=2)=[O:17])[CH3:20].[OH2:12]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of ethyl 4-chloro-6-ethoxy-7-methyl-1,8-naphthyridine-3-carboxylate (1.3 g), 6-amino-2-ethoxy pyridine (0.68 g), IMS (25 ml) and concentrated hydrochloric acid (2 drops) was boiled under reflux for 18 hours. The mixture was cooled and filtered to give ethyl 6-ethoxy-4-(6-ethoxy-2-pyridylamino)-7-methyl-1,8-naphthyridine-3-carboxylate sesquihydrochloride hydrate, m.p. 195°-200° C. Active (1/1) at 30 mg/kg.