4-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine → 2-(Methylsulfonyl)thieno[2,3-d]pyrimidine

HRID 19570

Reaktionsgleichung

Reaktionsgleichung von HRID 19570
Cl[C:2]1[C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[N:7]=1>C(O)C>[CH3:11][S:8]([C:6]1[N:7]=[CH:2][C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=1)(=[O:9])=[O:10]

Komponenten

3

Edukt 1

HCID 219883544-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine

Produkt 1

HCID 219883562-(Methylsulfonyl)thieno[2,3-d]pyrimidineAusbeute 85,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.

Aufarbeitung

  1. customwas bubbled for 5 minutes
  2. additionTo this solution was added 10% palladium on activated charcoal (15 g)
  3. customTo the resulting mixture was bubbled hydrogen gas over night
  4. filtrationThe reaction mixture was filtered through Celite
  5. concentrationThe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-398d0eeeef004e768af1392b96843f9b
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745449B2

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