Triethylamine → 1-Ethyl-3-(naphthalen-2-yl)-2-thioxo-imidazolidin-4-one

HRID 1957319

Reaktionsgleichung

Reaktionsgleichung von HRID 1957319
[CH2:1]([NH:3][CH2:4][C:5]([OH:7])=O)[CH3:2].[CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][C:9]=1[N:18]=[C:19]=[S:20].C(N(CC)CC)C>C(Cl)Cl>[CH2:1]([N:3]1[CH2:4][C:5](=[O:7])[N:18]([C:9]2[CH:10]=[CH:11][C:12]3[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:8]=2)[C:19]1=[S:20])[CH3:2]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 742222-NaphthylisothiocyanateHCID 316542N-Ethylglycine

Produkt 1

HCID 112887021-Ethyl-3-(naphthalen-2-yl)-2-thioxo-imidazolidin-4-oneAusbeute 34,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The tide compound was prepared by the procedure described in Example 4 using 9.2 g of N-ethyl glycine, 9.3 g of 2-naphthyl-isothiocyanate, 10.1 g of triethylamine, and 150 mL of methylene chloride. Purification was achieved through crystallization from ethanol. Title compound (4.7 g) was obtained as a light pink solid, m.p. 156°-159° C. Anal. Calcd. for. C15H14N2O S: C, 66.64; H, 5.22; N, 10.36 Found: C, 66.69; H,5.24; N, 10.42. Mass spectrum (El, M.+) m/z 270.

Aufarbeitung

  1. customThe tide compound was prepared by the procedure
  2. customPurification
  3. customwas achieved through crystallization from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-1eb7e58568b8422e9031d00812c2c3ad
Quelldatensatz
uspto-grants-1998_07
Patentnummer
US05783707

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