2,5-Dichlorophenol → 2,5-Dichloro-4-nitrophenol

HRID 1957470

Reaktionsgleichung

Reaktionsgleichung von HRID 1957470
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[N+:10]([O-])([OH:12])=[O:11]>ClCCl>[Cl:1][C:2]1[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]([Cl:8])=[CH:4][C:3]=1[OH:9]

Komponenten

4

Edukt 2

HCID 662,5-DichlorophenolHCID 944Nitric Acid

Produkt 1

HCID 221082,5-Dichloro-4-nitrophenolAusbeute 31 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2,5-dichlorophenol (72 g, 440 mmol) were slurried in 100 ml dichloromethane which resulted in an endothermic reaction. To this mixture were slowly added 30 ml (480 mmol) concentrated nitric acid. The reaction was allowed to reach and maintain reflux. The mixture was stirred until it reached ambient temperature and all materials remained in solution. 50 g of ice were added and solids precipitated. The mixture was filtered cold and washed with 25 ml dichloromethane, 50 ml dichloromethane, then twice with 25 ml dichloromethane to yield 28.4 g of 2,5-dichloro-4-nitrophenol.

Aufarbeitung

  1. customresulted in an endothermic reaction
  2. temperaturemaintain
  3. temperaturereflux
  4. customreached ambient temperature
  5. customsolids precipitated
  6. filtrationThe mixture was filtered cold
  7. washwashed with 25 ml dichloromethane, 50 ml dichloromethane

Quellen und Nachweise

ORD-Eintrag
ord-dac27d0877c748b2bf7ed384d762bcf7
Quelldatensatz
uspto-grants-1998_07
Patentnummer
US05786301

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