Sodium Hydroxide → HCID 19068157, Verbindung

HRID 1957577Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1957577
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:22]=[C:21]([C:23]([O:25]C)=[O:24])[O:20][N:19]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[OH-].[Na+]>CO>[C:1]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[O:20][N:19]=2)[CH2:12][CH2:13]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 19068171HCID 19068171, Verbindung

Produkt 1

HCID 19068157HCID 19068157, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 3-6 (580 mg, 1.6 mmol), 1N NaOH (3.1 mL, 3.1 mmol), and CH3OH (8 mL) was stirred at ambient temperature for 1.0 h. The reaction was then concentrated and the resulting gum acidified with 1M NaHSO4. The aqueous layer was saturated with NaCl and then extracted with ether. The extracts were combined, dried (MgSO4) and concentrated to give 3-7 as a viscous gum. Rf 0.20 (silica, 9/0.5/0.5 CH2Cl2/CH3OH/HOAc).

Aufarbeitung

  1. concentrationThe reaction was then concentrated
  2. extractionextracted with ether
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-9f21d1109f1642879f64c6683b606e68
Quelldatensatz
uspto-grants-1998_07
Patentnummer
US05786373

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