Sodium methanesulfinate → 1-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene

HRID 1957956Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1957956
Cl[CH2:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.[Na+].[CH3:17][S:18]([O-:20])=[O:19]>CO>[CH3:17][S:18]([CH2:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1)(=[O:20])=[O:19]

Komponenten

4

Edukt 2

HCID 2733271Sodium methanesulfinateHCID 684250951-(Chloromethyl)-3-nitro-5-(trifluoromethyl)benzene

Produkt 1

HCID 684233041-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzeneAusbeute 92,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-chloromethyl-3-nitro-5-trifluoromethyl-benzene (520 mg; 2.170 mmol) and methanesulfinic acid sodium salt (664 mg; 6.511 mmol) in Methanol (10 ml) of was refluxed overnight. The reaction was then cooled to room temperature and the product precipitated was filtered and diluted with dichloromethane. The solid was removed and the organic phase was concentrated in vacuo 520 mg (2 mmol; 85% yield) of 1-methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene were obtained.

Aufarbeitung

  1. customthe product precipitated
  2. filtrationwas filtered
  3. additiondiluted with dichloromethane
  4. customThe solid was removed

Quellen und Nachweise

ORD-Eintrag
ord-c521c703272c4832b7d389f592e4fd42
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410100B2

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