Dimethylamine → Dimethyl-[2-(3-nitro-benzenesulfonyl)-ethyl]-amine

HRID 1957978Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1957978
[N+:1]([C:4]1[CH:5]=[C:6]([S:10]([CH2:13][CH2:14]O)(=[O:12])=[O:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH3:16][NH:17][CH3:18]>C(O)C.ClCCl>[CH3:16][N:17]([CH3:18])[CH2:14][CH2:13][S:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)(=[O:12])=[O:11]

Komponenten

5

Edukt 2

HCID 674DimethylamineHCID 170561Ethanol, 2-[(3-nitrophenyl)sulfonyl]-

Produkt 1

HCID 68425174Dimethyl-[2-(3-nitro-benzenesulfonyl)-ethyl]-amineAusbeute 59,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(3-Nitro-phenylsulfonyl)-ethanol (0.5 g; 2.6 mmol) was dissolved in 3 mL ethanol and 2 mL of dichloromethane. Then 1 mL of (7.8 mmol) dimethylamine (33% in ethanol) was added, the reaction mixture was subsequently concentrated in vacuo, dissolved in dichloromethane, and the product was precipitated by adding diethyl ether and petrol ether. 0.4 g (1.55 mmol; 59% yield) of dimethyl-[2-(3-nitro-benzenesulfonyl)-ethyl]-amine were obtained as a yellow solid.

Aufarbeitung

  1. concentrationthe reaction mixture was subsequently concentrated in vacuo
  2. dissolutiondissolved in dichloromethane
  3. customthe product was precipitated
  4. additionby adding diethyl ether and petrol ether

Quellen und Nachweise

ORD-Eintrag
ord-201a381533a24327bfc9497915fbee9a
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410100B2

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