Oxolan-3-amine → HCID 66643845, Verbindung
Reaktionsgleichung
CO[C:3]([C:5]1[N:6]=[N:7][C:8]([O:11][CH2:12][C:13]2[C:14]([CH2:19][CH2:20][CH2:21][CH3:22])=[N:15][O:16][C:17]=2[CH3:18])=[CH:9][CH:10]=1)=[O:4].[O:23]1[CH2:27][CH2:26][CH:25]([NH2:28])[CH2:24]1>>[O:23]1[CH2:27][CH2:26][CH:25]([NH:28][C:3]([C:5]2[N:6]=[N:7][C:8]([O:11][CH2:12][C:13]3[C:14]([CH2:19][CH2:20][CH2:21][CH3:22])=[N:15][O:16][C:17]=3[CH3:18])=[CH:9][CH:10]=2)=[O:4])[CH2:24]1Komponenten
3
Versuchsvorschrift
As described for example 1e, 6-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-pyridazine-3-carboxylic acid methyl ester (120 mg, 0.39 mmol) was converted, using rac-tetrahydrofuran-3-amine instead of isopropylamine, to the title compound (130 mg, 92%) which was obtained as a light yellow oil after purification by chromatography (silica, 0 to 5% methanol in dichloromethane). MS: m/e=361.5 [M+H]+.
Quellen und Nachweise
- ORD-Eintrag
- ord-fae9bb8da3034930a84be35b291258b6
- Quelldatensatz