HCID 86619885, Verbindung → 1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

HRID 1959025Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1959025
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

Komponenten

3

Edukt 1

HCID 86619885HCID 86619885, Verbindung2×

Produkt 1

HCID 52261,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

Aufarbeitung

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

Quellen und Nachweise

ORD-Eintrag
ord-f6ae1292f80f47468c03cc8cd7891b81
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410123B2

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