N-Methylisopropylamine → 2-Bromo-N-isopropyl-N-methyl-acetamide

HRID 1959572

Reaktionsgleichung

Reaktionsgleichung von HRID 1959572
[CH:1]([NH:4][CH3:5])([CH3:3])[CH3:2].[N+](C1C=C([N+]([O-])=O)C=CC=1O[C:19](=[O:22])[CH2:20][Br:21])([O-])=O>C(Cl)Cl>[Br:21][CH2:20][C:19]([N:4]([CH:1]([CH3:3])[CH3:2])[CH3:5])=[O:22]

Komponenten

4

Edukt 2

HCID 78485N-MethylisopropylamineHCID 11278141Bromo-acetic acid 2,4-dinitro-phenyl ester

Produkt 1

HCID 205943482-Bromo-N-isopropyl-N-methyl-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Isopropyl-methyl-amine (154 μL, 1.48 mmol) was added to a stirred solution of bromo-acetic acid 2,4-dinitro-phenyl ester (450 mg, 1.48 mmol) in DCM (4 mL). After stirring for 3 h at room temperature the organic layer was extracted twice with 0.1 M NaOH solution (30 mL). The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The resulting title compound was used for the next reaction without purification. MS (m/z): 194.0 [M+H+].

Aufarbeitung

  1. extractionwas extracted twice with 0.1 M NaOH solution (30 mL)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe resulting title compound was used for the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-42b1851bbde7487390a5cbecead28780
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410134B2

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