Dichloromethane → N-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl]-isobutyramide

HRID 1959576Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1959576
[Cl:1][C:2]1[C:3]([CH2:10][O:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:4]([CH2:8][NH2:9])[CH:5]=[N:6][CH:7]=1.C(Cl)Cl.[C:21](Cl)(=[O:25])[CH:22]([CH3:24])[CH3:23]>>[Cl:1][C:2]1[C:3]([CH2:10][O:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:4]([CH2:8][NH:9][C:21](=[O:25])[CH:22]([CH3:24])[CH3:23])[CH:5]=[N:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 6344DichloromethaneHCID 62325Isobutyryl chlorideHCID 67077948C-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-methylamine

Produkt 1

HCID 67077454N-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl]-isobutyramide

Versuchsvorschrift

To a solution of C-[5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-methylamine (0.37 g, 1.4 mmol) in DCM (20 mL) DIPEA (0.41 mL, 2.2 mmol) and isobutyryl chloride (0.18 mL, 1.6 mmol) were added. Stirring was continued overnight at RT. The solvent was evaporated and the residue was used in the following step without further purification. MS (m/z): 326.9 [M+H+].

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue was used in the following step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4b5d426e0bc24c26b47b8a0118b8b7b0
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410134B2

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