Triacetoxyperiodinane → HCID 86645365, Verbindung

HRID 1959614Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1959614
CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O.[Cl:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]([CH2:30][OH:31])[C:25]=1[CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1>C1COCC1>[Cl:23][C:24]1[CH:29]=[CH:28][N:27]=[C:26]([CH:30]=[O:31])[C:25]=1[CH2:32][O:33][CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][O:35]1

Komponenten

4

Edukt 2

HCID 159087TriacetoxyperiodinaneHCID 67077239HCID 67077239, Verbindung

Produkt 1

HCID 86645365HCID 86645365, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Dess-Martin periodinane (370 mg. 0.873 mmol) was added to a stirred solution of [4-chloro-3-(tetrahydro-pyran-2-yloxymethyl)-pyridin-2-yl]-methanol (150 mg. 0.582 mmol) in THF (5 mL). After stirring for 2 h at room temperature the reaction was concentrated. Sat. NaHCO3 solution (20 mL) was added and extracted three times with DCM (50 mL). The combined organic layers were dried over Na2SO4 filtered and concentrated in vacuo. The resulting title compound was used for the next reaction without purification. MS (m/z): 255.7 [M+H+].

Aufarbeitung

  1. concentrationwas concentrated
  2. additionSat. NaHCO3 solution (20 mL) was added
  3. extractionextracted three times with DCM (50 mL)
  4. dry with materialThe combined organic layers were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe resulting title compound was used for the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-f34771091b8047cdbc4552c352c45dfc
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410134B2

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