Methylamine → HCID 178483385, Verbindung

HRID 1959842Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1959842
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 178509116HCID 178509116, Verbindung

Produkt 1

HCID 178483385HCID 178483385, VerbindungAusbeute 32 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

Aufarbeitung

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-ba9730bcfda44e219843ae63e21a3455
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08410272B2

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