[4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester → {4-[4-(5-Biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester

HRID 19600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 19600
[C:1]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11](S(C)(=O)=O)[N:10]3[N:17]=[CH:18][CH:19]=[C:9]3[CH:8]=2)=[CH:3][CH:2]=1.[C:26]([O:30][C:31](=[O:50])[NH:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([C:40](=[O:49])[NH:41][C:42]2[CH:47]=[CH:46][C:45]([NH2:48])=[CH:44][CH:43]=2)=[CH:36][CH:35]=1)([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31](=[O:50])[NH:32][CH2:33][C:34]1[CH:39]=[CH:38][C:37]([C:40](=[O:49])[NH:41][C:42]2[CH:43]=[CH:44][C:45]([NH:48][C:11]3[N:10]4[N:17]=[CH:18][CH:19]=[C:9]4[CH:8]=[C:7]([C:4]4[CH:5]=[CH:6][C:1]([C:20]5[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=5)=[CH:2][CH:3]=4)[N:12]=3)=[CH:46][CH:47]=2)=[CH:36][CH:35]=1)([CH3:29])([CH3:27])[CH3:28]

Komponenten

3

Edukt 2

HCID 67319189[4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl esterHCID 673194015-Biphenyl-4-yl-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine2×

Produkt 1

HCID 67319580{4-[4-(5-Biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

Under an inert gas atmosphere at 130° C. bath temperature is heated neat a mixture of 5-biphenyl-4-yl-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine (compound B1) and [4-(4-amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester (compound G1) overnight. The crude product is purified by silica gel flash chromatography.

Aufarbeitung

  1. customThe crude product is purified by silica gel flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-7bb89b1754674576bfaa0c2cfa3b5187
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745446B2

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