6-Bromo-3-hydroxy-3-methylindolin-2-one → 6-Bromo-3-methyl-1H-indole

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A mixture of 6-bromo-3-hydroxy-3-methyl-1,3-dihydro-2H-indol-2-one (0.25 g, 1.0 mmol) and BH3—S(CH3)2 (5.16 mL. 1.0 M, 5.16 mmol) in THF (20 mL) was heated at 60° C. The reaction was quenched with MeOH. Volatiles were removed. Chromatography over silica eluting with 4:1 hexane:EtOAc afforded the title compound. LC-MS: calculated for C9H8BrN: 210.07, observed m/e 211.0 (M+H)+ (Rt 1.14 min).

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