7-Methanesulfonyl-5-(4'-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidine → (4-{4-[5-(4'-Methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

HRID 19604Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 19604
CS([C:5]1[N:10]2[N:11]=[CH:12][CH:13]=[C:9]2[CH:8]=[C:7]([C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[CH:17]=[CH:18][CH:19]=2)[N:6]=1)(=O)=O.[C:28]([O:32][C:33](=[O:52])[NH:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39]([C:42](=[O:51])[NH:43][C:44]2[CH:49]=[CH:48][C:47]([NH2:50])=[CH:46][CH:45]=2)=[CH:38][CH:37]=1)([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33](=[O:52])[NH:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39]([C:42](=[O:51])[NH:43][C:44]2[CH:45]=[CH:46][C:47]([NH:50][C:5]3[N:10]4[N:11]=[CH:12][CH:13]=[C:9]4[CH:8]=[C:7]([C:14]4[CH:15]=[C:16]([C:20]5[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=5)[CH:17]=[CH:18][CH:19]=4)[N:6]=3)=[CH:48][CH:49]=2)=[CH:38][CH:37]=1)([CH3:31])([CH3:29])[CH3:30]

Komponenten

3

Edukt 2

HCID 673176537-Methanesulfonyl-5-(4'-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidineHCID 67319189[4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester2×

Produkt 1

HCID 67319203(4-{4-[5-(4'-Methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

Under an inert gas atmosphere at 130° C. bath temperature is heated neat a mixture of 7-methanesulfonyl-5-(4′-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidine and [4-(4-amino-phenylcarbamoyl)-benzyl]-carbamic acid tertbutyl ester (compound B3) overnight. The crude product is purified by silica gel flash chromatography.

Aufarbeitung

  1. customThe crude product is purified by silica gel flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-4b05f3aff05e4cd38be34cf9b4a03da6
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07745446B2

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