Acetyl chloride → HCID 178471808, Verbindung

HRID 1961655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1961655
Cl.[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9][CH2:8]1)[CH3:3].CCN(CC)CC.[C:22](Cl)([CH3:24])=[O:23]>C(Cl)Cl>[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([NH:13][C:22](=[O:23])[CH3:24])[CH2:11][CH2:12]1)[CH3:3]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 178471807HCID 178471807, Verbindung2×

Produkt 1

HCID 178471808HCID 178471808, VerbindungAusbeute 82,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(trans-4-Amino-cyclohexyl)-acetic acid ethyl ester hydrochloride (10.0 g, 45 mmol, intermediate B) was dissolved in CH2Cl2 (150 ml) and Et3N and AcCl (3.89 g, 50 mmol) were added. The reaction mixture was stirred 3 h at room temperature before washing it with H2O and brine. After drying (Na2SO4) the solvent was evaporated to yield 8.42 g (82%, 37 mmol) of a white solid. MS (m/z): 228.3 ([M+H]+).

Aufarbeitung

  1. washbefore washing it with H2O and brine
  2. dry with materialAfter drying (Na2SO4) the solvent
  3. customwas evaporated

Quellen und Nachweise

ORD-Eintrag
ord-3f4fe37a8cd743969f0adc1b37292c10
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415350B2

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