Sodium Hydroxide → (5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid

HRID 1962368Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1962368
C[O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[C:9]([CH:11]2[CH2:13][CH2:12]2)[C:8]([CH3:14])=[CH:7][C:6]=1[CH3:15].[OH-].[Na+]>CO>[CH:11]1([C:9]2[C:8]([CH3:14])=[CH:7][C:6]([CH3:15])=[C:5]([CH2:4][C:3]([OH:16])=[O:2])[CH:10]=2)[CH2:12][CH2:13]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 59614579(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester

Produkt 1

HCID 59614593(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acidAusbeute 98,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2.5 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester in 30 ml of methanol was kept at ice bath temperature and treated with 0.5 g of sodium hydroxide in 5 portions. The reaction mixture was stirred at room temperature for 1.5 hours. The solvent was removed in vacuo, the residue poured into water and extracted with diethyl ether. The combined organic phases were dried with sodium sulfate, filtered and concentrated to afford 2.3 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid.

Aufarbeitung

  1. customThe solvent was removed in vacuo
  2. additionthe residue poured into water
  3. extractionextracted with diethyl ether
  4. dry with materialThe combined organic phases were dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ccc0ac7a637f4331bd30443462201ccb
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415369B2

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