Hydrochloride methanol → Hydrochloric Acid

HRID 1962422Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1962422
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:28]

Komponenten

4

Edukt 2

HCID 21893726Hydrochloride methanolHCID 67242852(S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Produkt 2

HCID 313Hydrochloric AcidHCID 16223985(S)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

Versuchsvorschrift

Intermediate 1a (120 mg) prepared in Step A mentioned above was added with 10% hydrogen chloride/methanol (2 ml, Tokyo Kasei Kogyo), and the mixture was stirred at room temperature for 12 hours. The solvent was concentrated under reduced pressure, and the obtained solid was collected by filtration to obtain the title compound as hydrochloride (84 mg).

Aufarbeitung

  1. concentrationThe solvent was concentrated under reduced pressure
  2. filtrationthe obtained solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-334c021098a8453baa66a3bfdf772bbb
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415372B2

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