Ammonia → 6-Methylnicotinamide
Reaktionsgleichung
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6](OC)=[O:7])=[CH:4][N:3]=1.[NH3:12]>>[CH3:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH2:12])=[O:7])=[CH:4][N:3]=1Komponenten
3
Versuchsvorschrift
A mixture of methyl 6-methylnicotinate (13.9 g) and 28% aqueous ammonia (140 mL) was stirred at room temperature for 4 hr. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from ethanol to give the title compound as a white solid (yield 8.98 g, 72%).
Aufarbeitung
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe residue was recrystallized from ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-a091127d9ba548eeb556a0a9c3b137a5
- Quelldatensatz
- uspto-grants-2013_04
- Patentnummer
- US08415368B2
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