Phosphorus oxychloride → 2-Chloro-4-difluoromethyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine
Reaktionsgleichung
[F:1][CH:2]([F:20])[C:3]1[NH:8][C:7](=O)[N:6]=[C:5]([C:10]2[CH:11]=[N:12][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:14][CH:15]=2)[CH:4]=1.O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:7]1[N:8]=[C:3]([CH:2]([F:20])[F:1])[CH:4]=[C:5]([C:10]2[CH:11]=[N:12][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:14][CH:15]=2)[N:6]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 6-difluoromethyl-4-(6-trifluoromethyl-pyridin-3-yl)-1H-pyrimidin-2-one (6.37 g, 0.022 mol) and phosphoroxychloride (34 ml) according to the general procedure I. Obtained as a brown oil (6.65 g, 98%). MS (ISP) 310.2 [(M+H)+].
Quellen und Nachweise
- ORD-Eintrag
- ord-167395a9478a426ba05e6d254c90052b
- Quelldatensatz
- uspto-grants-2013_04