HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-methyl-1H-pyrazol-4-amine dihydrochloride → 5-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-methyl-1H-pyrazol-4-amine dihydrochloride | HCID 44890753 | — |
| Edukt | 5-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid | HCID 66644648 | — |
| Produkt | 5-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide | HCID 49803586 | 90% |
Reaktionsschritte
As described for example 7, 5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using 1-methyl-1H-pyrazol-4-ylamine dihydrochloride instead of isopropylamine, to the title compound (113 mg, 90%), which was obtained as a white solid. MS: m/e=391.1 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08415379B2 |
| Quelldatensatz | uspto-grants-2013_04 |
| ORD ID | ord-47997a2828bc4877b03341a893072928 |
| Quellennotiz | uspto-grants-2013_04 |