2-(Phenylmethyl)pyridine → 2-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizine

HRID 1963043Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1963043
Br[CH2:2][C:3](=O)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12].[CH2:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[F:11][C:7]1[C:6]([CH3:12])=[C:5]([CH:10]=[CH:9][CH:8]=1)[CH2:4][C:3]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:21]2[N:22]([CH:2]=1)[CH:23]=[CH:24][CH:25]=[CH:26]2

Komponenten

4

Edukt 2

HCID 75812-(Phenylmethyl)pyridineHCID 866706671-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one

Produkt 1

HCID 677730242-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizineAusbeute 33,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

The compound of step 2 (1.50 g, 6.12 mmol) and 2-benzyl-pyridine (2.071 g, 12.24 mmol) were dissolved in acetone (30 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (cyclohexane) to give 0.653 g of the title compound.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. concentrationThe mixture was concentrated to dryness
  3. customthe residue was purified by chromatography on silica gel (cyclohexane)

Quellen und Nachweise

ORD-Eintrag
ord-a857ff382b0a4e8abaa8d4ebf918fd2d
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415336B2

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