2-(Phenylmethyl)pyridine → HCID 67772676, Verbindung

HRID 1963049Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1963049
Br[CH2:2][C:3](=O)[CH2:4][C:5]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:12].[CH2:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[Cl:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:5]=1[CH2:4][C:3]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:21]2[N:22]([CH:2]=1)[CH:23]=[CH:24][CH:25]=[CH:26]2

Komponenten

4

Edukt 2

HCID 75812-(Phenylmethyl)pyridineHCID 80147526HCID 80147526, Verbindung

Produkt 1

HCID 67772676HCID 67772676, VerbindungAusbeute 76,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

The compound of step 1 (1.17 g, 4.41 mmol) and 2-benzyl-pyridine (1.49 g, 8.82 mmol) were dissolved in acetone (15 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (DCM/MOH, 100:0, then 95:5) to give 1.13 g of the title compound.

Aufarbeitung

  1. temperatureunder reflux overnight
  2. concentrationThe mixture was concentrated to dryness
  3. customthe residue was purified by chromatography on silica gel (DCM/MOH, 100:0

Quellen und Nachweise

ORD-Eintrag
ord-f019980b3a7a4707b5c4643159388c93
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415336B2

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