Tert-butyl 2-isobutyl-4,6-dioxopiperidine-1-carboxylate → 6-(2-methylpropyl)piperidine-2,4-dione

HRID 1963108Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1963108
[CH2:1]([CH:5]1[CH2:10][C:9](=[O:11])[CH2:8][C:7](=[O:12])[N:6]1C(OC(C)(C)C)=O)[CH:2]([CH3:4])[CH3:3]>O1CCOCC1.Cl>[CH2:1]([CH:5]1[NH:6][C:7](=[O:12])[CH2:8][C:9](=[O:11])[CH2:10]1)[CH:2]([CH3:4])[CH3:3]

Komponenten

4

Edukt 1

HCID 25193505Tert-butyl 2-isobutyl-4,6-dioxopiperidine-1-carboxylate

Produkt 1

HCID 52466806-(2-methylpropyl)piperidine-2,4-dioneAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To a solution of tert-butyl 2-isobutyl-4,6-dioxopiperidine-1-carboxylate (30 g, 0.114 mol) in dry 1,4 dioxane (300 mL), HCl (3 M in 1,4 dioxane, 100 mL) was added and stirred at room temperature for 3 h. The reaction mixture was concentrated and purified by crystallization using diethyl ether to yield 6-isobutyl-piperidine-2,4-dione (14 g, 74%) as a white solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by crystallization

Quellen und Nachweise

ORD-Eintrag
ord-28b3f65439014170881e12cb196dcaf2
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415378B2

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