Benzylamine → N-benzyl-3-[(4-tert-butylphenyl)sulfonyl]-1,3-thiazolidine-2-carboxamide

HRID 1964829

Reaktionsgleichung

Reaktionsgleichung von HRID 1964829
C(OC([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=O)(C)(C)C.C1C=CC(/[C:22](/[C:25]2[CH:30]=[CH:29][C:28]([N+]([O-])=O)=[CH:27][CH:26]=2)=[N:23]/O)=CC=1.[C:34]([C:38]1[CH:43]=[CH:42][C:41]([S:44](Cl)(=[O:46])=[O:45])=[CH:40][CH:39]=1)([CH3:37])([CH3:36])[CH3:35].C(N)C1C=CC=CC=1>>[CH2:22]([NH:23][C:13]([CH:9]1[N:8]([S:44]([C:41]2[CH:42]=[CH:43][C:38]([C:34]([CH3:37])([CH3:36])[CH3:35])=[CH:39][CH:40]=2)(=[O:46])=[O:45])[CH2:12][CH2:11][S:10]1)=[O:15])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Komponenten

5

Edukt 4

HCID 7504BenzylamineHCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 46440943-(tert-Butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acidHCID 6506582Benzophenone, 4-nitro-, oxime

Produkt 1

HCID 11339104N-benzyl-3-[(4-tert-butylphenyl)sulfonyl]-1,3-thiazolidine-2-carboxamide

Versuchsvorschrift

Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 4-tert-butylbenzenesulfonyl chloride and benzylamine, the title compound was obtained in 97.1% purity by HPLC.

Quellen und Nachweise

ORD-Eintrag
ord-9c8311136e4b4fc89c2db75a6c57dc15
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415480B2

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