(2-Thienylmethyl)amine → 3-([1,1'-biphenyl]-4-ylsulfonyl)-N-(2-thienylmethyl)-1,3-thiazolidine-2-carboxamide

HRID 1964830

Reaktionsgleichung

Reaktionsgleichung von HRID 1964830
C(OC([N:8]1[CH2:12][CH2:11][S:10][CH:9]1[C:13]([OH:15])=O)=O)(C)(C)C.C1C=CC(/C(/C2C=CC([N+]([O-])=O)=CC=2)=N/O)=CC=1.[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40](Cl)(=[O:42])=[O:41])=[CH:36][CH:35]=1.[S:50]1[CH:54]=[CH:53][CH:52]=[C:51]1[CH2:55][NH2:56]>>[C:34]1([C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)[CH:39]=[CH:38][C:37]([S:40]([N:8]2[CH2:12][CH2:11][S:10][CH:9]2[C:13]([NH:56][CH2:55][C:51]2[S:50][CH:54]=[CH:53][CH:52]=2)=[O:15])(=[O:42])=[O:41])=[CH:36][CH:35]=1

Komponenten

5

Edukt 4

HCID 34005(2-Thienylmethyl)amineHCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 46440943-(tert-Butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acidHCID 6506582Benzophenone, 4-nitro-, oxime

Produkt 1

HCID 101514613-([1,1'-biphenyl]-4-ylsulfonyl)-N-(2-thienylmethyl)-1,3-thiazolidine-2-carboxamide

Versuchsvorschrift

Following the general solid phase method as outlined Example 33, starting from 3-(tert-butoxycarbonyl)-1,3-thiazolidine-2-carboxylic acid, Kaiser oxime resin, 1,1′-biphenyl-4-sulfonyl chloride and 2-thienylmethanamine, the title compound was obtained in 94% purity by HPLC.

Quellen und Nachweise

ORD-Eintrag
ord-1212af19b862411d87b40ca0ff8c8087
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415480B2

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