6-bromo-1'-(diphenylmethyl)spiro[1-benzofuran-3,3'-indol]-2'(1H)-one → 6-bromospiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 1965471Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1965471
[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([CH2:31][O:32][C:4]=2[CH:3]=1)[C:16]1[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=1)[N:10](C(C1C=CC=CC=1)C1C=CC=CC=1)[C:9]3=[O:30].C1(C(C2C=CC=CC=2)N2C3C(=CC=CC=3)C3(C4C=C(C)C(OC)=CC=4OC3)C2=O)C=CC=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3([CH2:31][O:32][C:4]=2[CH:3]=1)[C:16]1[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=1)[NH:10][C:9]3=[O:30]

Komponenten

3

Edukt 2

HCID 461941846-bromo-1'-(diphenylmethyl)spiro[1-benzofuran-3,3'-indol]-2'(1H)-oneHCID 593524081'-(diphenylmethyl)-6-methoxy-5-methylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Produkt 1

HCID 461940506-bromospiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Versuchsvorschrift

Following the procedure as described in EXAMPLE 3 and making non-critical variations using 6-bromo-1′-(diphenylmethyl)spiro[1-benzofuran-3,3′-indol]-2′(1′H)-one to replace 1′-(diphenylmethyl)-6-methoxy-5-methylspiro[1-benzofuran-3,3′-indol]-2′(1′H)-one, 6-bromospiro[1-benzofuran-3,3′-indol]-2′(1′H)-one was obtained (89%) as a colorless solid: MS (ES+) m/z 316.1 (M+1), 318.1 (M+1).

Quellen und Nachweise

ORD-Eintrag
ord-cb4b65369da5487f8cb734760bd855e5
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415370B2

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