Tetrahydrofuran → N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

HRID 1965944Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1965944
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1.[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14]Cl.C(=O)(O)[O-].[Na+].O1CCCC1>CO>[CH3:11][N:12]([CH3:17])[C:13](=[O:16])[CH2:14][N:2]([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 758862-chloro-N,N-dimethylacetamideHCID 143276Methyl[2-(pyridin-4-yl)ethyl]amineHCID 516892Sodium Bicarbonate

Produkt 1

HCID 21081298N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

4-[2-(methylamino)ethyl]pyridine (34.4 g) and 29.18 g of chloroacetic acid-dimethylamide are dissolved in 200 ml of methanol. After the addition of 20 g of sodium bicarbonate the mixture is refluxed for 5 hours with stirring. For working up the mixture is combined with 1000 ml of tetrahydrofuran, decanted off from the precipitated salts and the solution is filtered through active charcoal. After the limination of the solvent, N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide is obtained as a crude product.

Aufarbeitung

  1. temperatureis refluxed for 5 hours
  2. customdecanted off from the precipitated salts
  3. filtrationthe solution is filtered through active charcoal

Quellen und Nachweise

ORD-Eintrag
ord-b2be16b18a5f48e1b6b82760038f2a74
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08420630B2

Notizen zur Reaktion

Wird geladen…