Hydrochloric Acid → [2,6-Difluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

HRID 1967144Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1967144
[F:1][C:2]1[CH:3]=[C:4]([C:13]([OH:16])([CH3:15])[CH3:14])[CH:5]=[C:6]([F:12])[C:7]=1[CH:8]=[CH:9][O:10]C.Cl>CC(C)=O>[F:1][C:2]1[CH:3]=[C:4]([C:13]([OH:16])([CH3:14])[CH3:15])[CH:5]=[C:6]([F:12])[C:7]=1[CH2:8][CH:9]=[O:10]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 670288782-{3,5-Difluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol

Produkt 1

HCID 59525773[2,6-Difluoro-4-(1-hydroxy-1-methyl-ethyl)-phenyl]-acetaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A solution of 2-{3,5-difluoro-4-[2-methoxyvinyl]phenyl}propan-2-ol (5.0 g, 22 mmol) in acetone (25 mL) was added dropwise to 4 M aqueous hydrochloric acid (25 mL, 100 mmol) with ice-water cooling, keeping the temperature below 10° C. Then the mixture was stirred at room temperature for six hours. The resulting mixture was extracted with ethyl acetate (2×) and the combined organic phases were washed with saturated aqueous sodium bicarbonate and brine. The organic layer was then dried and concentrated in vacuo to afford the title compound.

Aufarbeitung

  1. customthe temperature below 10° C
  2. extractionThe resulting mixture was extracted with ethyl acetate (2×)
  3. washthe combined organic phases were washed with saturated aqueous sodium bicarbonate and brine
  4. customThe organic layer was then dried
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a9adb692950945538ed751597b3f5a6f
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08420695B2

Notizen zur Reaktion

Wird geladen…