Trifluoroacetic acid → HCID 86654209, Verbindung

HRID 1968274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1968274
C([O:5][C:6](=[O:32])[C@H:7]([NH:10][CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]2[N:18](C(OC(C)(C)C)=O)[CH:19]=[C:20]([C:21]([O:23][CH3:24])=[O:22])[C:13]=12)[CH2:8][CH3:9])(C)(C)C.[C:33]([OH:39])([C:35]([F:38])([F:37])[F:36])=[O:34]>C(Cl)Cl>[F:36][C:35]([F:38])([F:37])[C:33]([OH:39])=[O:34].[CH3:24][O:23][C:21]([C:20]1[C:13]2[C:14](=[N:15][CH:16]=[CH:17][C:12]=2[CH2:11][NH:10][C@H:7]([CH2:8][CH3:9])[C:6]([OH:32])=[O:5])[NH:18][CH:19]=1)=[O:22]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 58293538HCID 58293538, Verbindung

Produkt 1

HCID 86654209HCID 86654209, VerbindungAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a 100 mL round bottom flask equipped for stirring was added (R)-1-tert-butyl 3-methyl 4-((1-tert-butoxy-1-oxobutan-2-ylamino)methyl)-1H-pyrrolo[2,3-b]pyridine-1,3-dicarboxylate (1.45 g, 3.24 mmol) and DCM (10 mL). TFA (10 mL) was added and the reaction mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated and dried in vacuo to afford the title compound as a yellow oil (1.3 g, 99%) (TFA salt). [M+H] calc'd for C14H17N3O4, 292; found, 292.6.

Aufarbeitung

  1. customTo a 100 mL round bottom flask equipped
  2. stirringthe reaction mixture was stirred at room temperature for 30 min
  3. concentrationThe reaction mixture was concentrated
  4. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-55832bbc04f14476801b0b97c08aa18e
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08420816B2

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