Ammonium Chloride → HCID 15952174, Verbindung

HRID 1968742Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1968742
CC(C)([O-:4])C.[K+].C[O:8][C:9](=[O:21])[C:10]([C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][CH:13]=1)=O.[Cl:22][C:23]1[C:24]([CH2:37][C:38]([NH2:40])=[O:39])=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]=[CH:28][C:27]([CH2:33][N:34]([CH3:36])[CH3:35])=[N:26]2.[NH4+].[Cl-]>O1CCCC1.CCOC(C)=O>[Cl:22][C:23]1[C:24]([C:37]2[C:38](=[O:39])[NH:40][C:9](=[O:21])[C:10]=2[C:12]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=2)=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]=[CH:28][C:27]([CH2:33][N:34]([CH3:35])[CH3:36])=[N:26]2.[CH3:35][N:34]([CH2:33][C:27]1[CH:28]=[N:29][C:30]2[C:25]([N:26]=1)=[C:24]([C:37]1[C:38](=[O:39])[NH:40][C:9](=[O:8])[C:10]=1[C:12]1[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[NH:14][CH:13]=1)[C:23]([OH:4])=[CH:32][CH:31]=2)[CH3:36]

Komponenten

8

Edukt 4

HCID 25517Ammonium ChlorideHCID 588944Methyl 3-indoleglyoxylateHCID 23665647Potassium tert-butoxideHCID 66882585HCID 66882585, Verbindung

Produkt 2

HCID 15952174HCID 15952174, VerbindungAusbeute 27 %HCID 136389672HCID 136389672, VerbindungAusbeute 12 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Potassium tert-butoxide (1.0 M in THF, 0.86 ml, 0.86 mmol, 4.0 equiv) was added at room temperature under an atmosphere of argon to a solution of (1H-indol-3-yl)-oxo-acetic acid methyl ester (66 mg, 0.32 mmol, 1.5 equiv) and of 2-(6-chloro-3-dimethylaminomethyl-quinoxalin-5-yl)-acetamide (60 mg, 0.22 mmol) in anhydrous tetrahydrofuran (3.0 ml, dried over molecular sieves). The reaction mixture was stirred for 15 minutes at room temperature. It was then diluted with EtOAc and poured into a saturated aqueous NH4Cl solution. After three extractions with EtOAc, the combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo. Purification of the residue via preparative HPLC afforded the title compound (32 mg, 27%) and 3-(3-dimethylaminomethyl-6-hydroxy-quinoxalin-5-yl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione (14 mg, 12%) as their trifluoroacetate salts. Data for 3-(6-chloro-3-dimethylaminomethyl-quinoxalin-5-yl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione: 1H NMR (400 MHz, d6-DMSO): δ=11.97 (s, 1H), 11.26 (s, 1H), 9.86 (s, 1H), 9.01 (s, 1H) 8.29 (d, J=9.0 Hz, 1H), 8.06-8.04 (m, 2H), 7.35 (d, J=8.0 Hz, 1H), 6.96 (dt, J=7.6/1.0 Hz, 1H), 6.49 (dt, J=8.1/1.0 Hz, 1H), 6.09 (d, J=8.3 Hz, 1H), 4.68 (s, 2H), 2.66 (s, 6H). MS (ES+): 432.2 (M+H)+. Data for 3-(3-dimethylaminomethyl-6-hydroxy-quinoxalin-5-yl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione: 1H NMR (400 MHz, d6-DMSO): δ=11.80 (s, 1H), 11.01 (s, 1H), 10.64 (s, 1H), 9.79 (s, 1H), 8.75 (s, 1H), 8.08 (d, J=9.3 Hz, 1H), 7.95 (d, J=2.9 Hz, 1H), 7.51 (d, J=9.0 Hz, 1H), 7.32 (d, J=8.1 Hz, 1H), 6.93 (dt, J=7.6/0.9 Hz, 1H), 6.48 (dt, J=8.1/1.0 Hz, 1H), 6.34 (d, J=8.3 Hz), 4.58 (s, 2H), 2.67 (s, 6H). MS (ES+): 414.3 (M+H)+.

Aufarbeitung

  1. extractionAfter three extractions with EtOAc
  2. dry with materialthe combined organic layers were dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customPurification of the residue via preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-be98dadf8c624b42bd47b207655d0772
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426440B2

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