Ethyl Acetate → 4-Amino-5-hydroxy-2-methylbenzonitrile
Reaktionsgleichung
[OH:1][C:2]1[C:3]([N+:11]([O-])=O)=[CH:4][C:5]([CH3:10])=[C:6]([CH:9]=1)[C:7]#[N:8].CCOC(C)=O>CCO>[NH2:11][C:3]1[C:2]([OH:1])=[CH:9][C:6]([C:7]#[N:8])=[C:5]([CH3:10])[CH:4]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
5-hydroxy-2-methyl-4-nitrobenzonitrile (D91, 185 mg, 1.04 mmol) was dissolved in EtOH:EtOAc (24 mL, 1:1) and was reduced using an H-Cube (full H2 mode, 25° C., 1 mL/min). The reaction was concentrated by rotary evaporation to give 4-amino-5-hydroxy-2-methylbenzonitrile (D92, 152 mg, 95%) as a pale yellow solid.
Aufarbeitung
- customan H-Cube (full H2 mode, 25° C., 1 mL/min)
- concentrationThe reaction was concentrated by rotary evaporation
Quellen und Nachweise
- ORD-Eintrag
- ord-19abe163285f44ef869912ec64b69e71
- Quelldatensatz
- uspto-grants-2013_04
- Patentnummer
- US08426443B2
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