Triethylamine → HCID 66669764, Verbindung

HRID 1969409Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1969409
[OH:1][CH:2]1[C:6]2([CH2:8][CH2:7]2)[CH2:5][NH:4][CH2:3]1.Br[CH2:10][CH2:11][CH2:12][OH:13].CCN(CC)CC>C1COCC1>[OH:1][CH:2]1[C:6]2([CH2:8][CH2:7]2)[CH2:5][N:4]([CH2:10][CH2:11][CH2:12][OH:13])[CH2:3]1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 123083-Bromo-1-propanolHCID 167382865-Azaspiro[2.4]heptan-7-ol

Produkt 1

HCID 66669764HCID 66669764, VerbindungAusbeute 60,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 7-hydroxy-5-azaspiro[2.4]heptane (1.23 g, 11.0 mmol) in THF (40 mL) was added 3-bromopropanol (2.3 g, 16.65 mmol) and Et3N (2.24 g, 22.2 mmol). The reaction mixture was stirred at rt for 12 hrs and then concentrated in vacuo. The residue was purified by a silica gel column chromatography (100:50:2(v/v/v) EtOAc/CH3OH/Et3N) to afford the desired compound as orange oil (1.14 g, 60%).

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by a silica gel column chromatography (100:50:2(v/v/v) EtOAc/CH3OH/Et3N)

Quellen und Nachweise

ORD-Eintrag
ord-e77ef172b54e454a86a7ccce6de63125
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426585B2

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