Trifluoroacetic acid → (R)-benzyl 2-methylpiperazine-1-carboxylate

HRID 1970541Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970541
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[C@H:10]([CH3:24])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]1[CH3:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 53886770(R)-4-Boc-1-Cbz-2-methyl-piperazine

Produkt 1

HCID 40424346(R)-benzyl 2-methylpiperazine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 4.3 g (R)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester in 20 ml dichloromethane was stirred in the presence of 10 ml TFA for 16 h. The solution was concentrated and the residue codistilled twice with toluene to give the crude hydrotrifluoroacetate. Yield: 6.1 g.

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customto give the crude hydrotrifluoroacetate

Quellen und Nachweise

ORD-Eintrag
ord-6a23a07fcd1442c288ef8fb2314ac3c4
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426420B2

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