Trifluoroacetic acid → Benzyl (2S)-2-methylpiperazine-1-carboxylate

HRID 1970546

Reaktionsgleichung

Reaktionsgleichung von HRID 1970546
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:15])[C@@H:10]([CH3:24])[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:17]([O:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@@H:10]1[CH3:24])=[O:15])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 29921716HCID 29921716, Verbindung

Produkt 1

HCID 40425199Benzyl (2S)-2-methylpiperazine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 4.3 g (S)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester in 20 ml dichloromethane was stirred in the presence of 10 ml TFA for 16 h. The solution was concentrated and the residue codistilled twice with toluene to give the crude hydrotrifluoroacetate. Yield: 6.4 g.

Aufarbeitung

  1. concentrationThe solution was concentrated
  2. customto give the crude hydrotrifluoroacetate

Quellen und Nachweise

ORD-Eintrag
ord-31083060ec4546e6bb1e81dcf4886988
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08426420B2

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