1-Benzyl 4-ethyl (2S)-2-methylpiperazine-1,4-dicarboxylate → Ethyl (3S)-3-methylpiperazine-1-carboxylate

Beteiligte Stoffe

Reaktionsschritte

A suspension of 3.5 g (S)-2-Methyl-piperazine-1,4-dicarboxylic acid 1-benzyl ester 4-ethyl ester and 0.4 g Pd/C (10%) in 56 ml ethyl acetate was stirred under an atmosphere of hydrogen (3 bar) for 12 h. The mixture was filtrated over a plug of Celite, washed with ethyl acetate and the combined wash solutions concentrated to give the title compound as colourless oil. Yield: 1.6 g.

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