Hydrochloric Acid → (1R)-1-Cyclopropyl-2,2,2-trifluoroethanaminium chloride
Reaktionsgleichung
[CH:1]1([C@@H:4]([NH:9]S(C(C)(C)C)=O)[C:5]([F:8])([F:7])[F:6])[CH2:3][CH2:2]1.[ClH:16].O1CCOCC1>CO>[Cl-:16].[CH:1]1([C@@H:4]([NH3+:9])[C:5]([F:8])([F:7])[F:6])[CH2:3][CH2:2]1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
N-[(1R)-1-Cyclopropyl-2,2,2-trifluoroethyl]-2-methylpropane-2-sulfinamide ((S,R), 16.55 g, 68.0 mmol) was dissolved in MeOH (34 ml) and 4 M HCl in dioxane (34.0 ml, 136 mmol) was added. The reaction mixture was allowed to stir for 30 min, and concentrated to half the volume. Ether was added to the mixture, and the resultant precipitate was collected by filtration to give the title compound.
Aufarbeitung
- concentrationconcentrated to half the volume
- additionEther was added to the mixture
- filtrationthe resultant precipitate was collected by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-e0b6faaaa9b748b3b7bb31eabf50e438
- Quelldatensatz
- uspto-grants-2013_04
- Patentnummer
- US08431569B2
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