Sodium Azide → HCID 59543137, Verbindung

HRID 1970988Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1970988
CS(O[CH:6]1[CH2:11][CH2:10][CH:9]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[CH:8]([F:20])[CH2:7]1)(=O)=O.[N-:21]=[N+:22]=[N-:23].[Na+]>CN(C=O)C.CCOC(C)=O>[N:21]([CH:6]1[CH2:11][CH2:10][CH:9]([O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14])[CH:8]([F:20])[CH2:7]1)=[N+:22]=[N-:23]

Komponenten

5

Edukt 2

HCID 33557Sodium AzideHCID 595431564-{[tert-Butyl(dimethyl)silyl]oxy}-3-fluorocyclohexyl methanesulfonate

Produkt 1

HCID 59543137HCID 59543137, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a stirred solution of 4-{[tert-butyl(dimethyl)silyl]oxy}-3-fluorocyclohexyl methanesulfonate (570 mg, 1.75 mmol) in DMF (10 mL) was added sodium azide (340 mg, 5.24 mmol). The reaction mixture was heated to 100° C. overnight, diluted with EtOAc, and washed with water. The organic layer was dried, concentrated, and purified by flash chromatography to afford the title compound.

Aufarbeitung

  1. washwashed with water
  2. customThe organic layer was dried
  3. concentrationconcentrated
  4. custompurified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-8b2a9d2461814b968369fa408eeedb35
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08431569B2

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