Potassium Carbonate → 9-tert-butyl-3-methoxy-2-pyridin-3-yl-14-(1,3-thiazol-5-yl)-5,6,10,11,12,13-hexahydroazocino[4',3':4,5]pyrrolo[2,1-a]isoquinolin-8(9H)-one

Reaktionsgleichung

Br[C:2]1[C:3]([O:31][CH3:32])=[CH:4][C:5]2[CH2:6][CH2:7][N:8]3[C:14]4[C:15](=[O:25])[N:16]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH2:17][CH2:18]O[CH2:20][C:13]=4[C:12]([C:26]4[S:30][CH:29]=[N:28][CH:27]=4)=[C:9]3[C:10]=2[CH:11]=1.B(O)(O)[C:34]1[CH:39]=[CH:38][CH:37]=[N:36][CH:35]=1.[C:42]([O-])([O-])=O.[K+].[K+].[OH-].[Na+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(COC)OC>[C:21]([N:16]1[CH2:17][CH2:18][CH2:42][CH2:20][C:13]2[C:12]([C:26]3[S:30][CH:29]=[N:28][CH:27]=3)=[C:9]3[C:10]4[CH:11]=[C:2]([C:34]5[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=5)[C:3]([O:31][CH3:32])=[CH:4][C:5]=4[CH2:6][CH2:7][N:8]3[C:14]=2[C:15]1=[O:25])([CH3:23])([CH3:22])[CH3:24]