Dimethyl Sulfide → 2-[(3-Methoxyphenyl)methyl]piperazine

To a 100-mL round-bottomed flask was added 3-(3-methoxybenzyl)-2,5-piperazinedione (201 mg, 0.858 mmol), 5 mL of THF and BH3.DMS (0.326 mL, 3.43 mmol, Aldrich, St. Louis, Mo.). The reaction mixture was stirred at 70° C. for 18 h and then diluted with 1N NaOH (12 mL) and extracted with CH2Cl2 (2×50 mL). The organic extracts were washed with saturated aqueous NaCl (5 mL) and dried over Na2SO4. The solution was filtered and concentrated in vacuo to give the crude 2-(3-methoxybenzyl)piperazine (152 mg) as a colorless tar.

1. extractionextracted with CH2Cl2 (2×50 mL)
2. washThe organic extracts were washed with saturated aqueous NaCl (5 mL)
3. dry with materialdried over Na2SO4
4. filtrationThe solution was filtered
5. concentrationconcentrated in vacuo

ORD-Eintrag

ord-3abeda7c35f6410a9d1347564d2e1778

Quelldatensatz

uspto-grants-2013_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08431563B2