Hydrochloric Acid → (5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

HRID 1973043Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1973043
[C:1]([C:3]1[O:4][C:5]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:6]=2[C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)#[N:2].B.Cl>O1CCCC1>[ClH:18].[NH2:2][CH2:1][C:3]1[O:4][C:5]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:6]=2[C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6331BoraneHCID 227634675-Chloro-3-phenyl-1-benzofuran-2-carbonitrile

Produkt 1

HCID 22763506(5-Chloro-3-phenyl-1-benzofuran-2-yl)methanamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Treat 2.0 g. 2-cyano-5-chloro-3-phenylbenzofuran (0.008 mole) in 30 ml of tetrahydrofuran with 18 ml of borane in tetrahydrofuran (1 m solution). Reflux for 2 hours. Cool, add 10 ml of 10% hydrochloric acid and reflux for 1/2 hour. Evaporate the solution to dryness. Dissolve the residue in 50 ml of ethanol. Add 30 ml of ethanol saturated with hydrogen chloride. Dry the precipitate obtained to yield the title compound; m.p. 254°-256°.

Aufarbeitung

  1. additionTreat 2.0 g
  2. temperatureReflux for 2 hours
  3. temperatureCool
  4. temperaturereflux for 1/2 hour
  5. customEvaporate the solution to dryness
  6. dissolutionDissolve the residue in 50 ml of ethanol
  7. additionAdd 30 ml of ethanol saturated with hydrogen chloride
  8. customDry the precipitate
  9. customobtained

Quellen und Nachweise

ORD-Eintrag
ord-02cf2179bba7498a9e959b46be91ec3b
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US03996159

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