21-Methyl-5alpha-pregnane-3,11,20-trione → 3alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione

HRID 1973715Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1973715
[CH3:1][CH2:2][C:3](=[O:25])[C@@H:4]1[C@:21]2([CH3:22])[C@H:7]([C@H:8]3[C@H:18]([C:19](=[O:23])[CH2:20]2)[C@:16]2([CH3:17])[C@H:11]([CH2:12][C:13](=[O:24])[CH2:14][CH2:15]2)[CH2:10][CH2:9]3)[CH2:6][CH2:5]1>O.Cl.Cl.Cl[Ir](Cl)(Cl)Cl>[OH:24][C@@H:13]1[CH2:14][CH2:15][C@@:16]2([CH3:17])[C@@H:11]([CH2:10][CH2:9][C@@H:8]3[C@@H:18]2[C:19](=[O:23])[CH2:20][C@@:21]2([CH3:22])[C@H:7]3[CH2:6][CH2:5][C@@H:4]2[C:3](=[O:25])[CH2:2][CH3:1])[CH2:12]1

Komponenten

3

Edukt 1

HCID 13171057521-Methyl-5alpha-pregnane-3,11,20-trione

Produkt 1

HCID 867342873alpha-Hydroxy-21-methyl-5alpha-pregnane-11,20-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 16211483Tetrachloroiridium--hydrogen chloride--water (1/2/1)Katalysator

Versuchsvorschrift

21-Methyl-5α-pregnane-3,11,20-trione (0.4 g.) was added to "stock" chloroiridic acid solution (75 ml.) and the resulting mixture was refluxed for 2 hr. The solution was then cooled and partitioned between water and ether. The organic layer was washed with saturated aqueous sodium bicarbonate, dried (Na2SO4) and evaporated.

Aufarbeitung

  1. temperaturethe resulting mixture was refluxed for 2 hr
  2. temperatureThe solution was then cooled
  3. custompartitioned between water and ether
  4. washThe organic layer was washed with saturated aqueous sodium bicarbonate
  5. dry with materialdried (Na2SO4)
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-74f27b354f7046d6a5fd64635496c2cf
Quelldatensatz
uspto-grants-1976_12
Patentnummer
US03998829

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